In my last post I looked at the GAG layer in the bladder and how damage to it can cause problems for the bladder lining, a.k.a the bladder urothelium.
When the bladder urothelium gets damaged it can lose its integrity and become ‘leaky’ or ‘hyper-permeable’. Molecules that shouldn’t normally leave the bladder can get into the space (‘interstitium’ – hence interstitial cystitis) between the layers of the tissue and into the blood.
The so-called GAG layer plays an important role in protecting the bladder lining (epithelium) against anything that enters the bladder.
When this protective layer is disturbed, the sensitive bladder lining is exposed to irritation and attack. From this, sensitivity, pain and other problems can arise.
A damaged GAG layer has been established to play a big role in the pathogenesis of interstitial cystitis.