Mast cells have long been reported to be raised in patients suffering from interstitial cystitis. Mast cells are a type of cell that are usually associated with allergies. Today I’m going to take a look at the relationship between interstitial cystitis and mast cells.
There is new(ish) evidence emerging that recurrent UTIs, also known as chronic cystitis, are not always caused by a reinfection with a new pathogen but rather can be a relapse of the same pathogen.
It turns out that pathogenic bacteria have the ability to invade the cells of the bladder and live there in a dormant sleep-like state.
This is called an ‘intracellular bacterial community’.
In this state, the bacteria remain undetected by standard urine testing and unaffected by antibiotic treatment. They also remain undetected by our own immune system.
Now and again they can leave the cells, causing a relapse of the urinary tract infection.
For anyone who has read my own story, you may remember that repeated courses of antibiotics for chronic UTIs kicked off my interstitial cystitis a few years ago. Can antibiotics cause interstitial cystitis and chronic UTIs? For me, they have definitely played a big role.
This question has been at the back of my mind for a while and today I would like to take a look at some of the scientific evidence to answer this question.
The current gold-standard testing for UTIs involves culturing the bacteria present in a clean-catch midstream urine sample (MSU) in a lab dish.
On top of that, a dipstick test is often used to indicate the presence of infection markers in urine.
The guidelines for these testing methods have been established in the 1950s. With the discovery of the urinary microbiome, inadequacies of this method have come to light.
It turns out that urine is in fact not sterile and that many microbial species cannot be cultured in a lab.
Therefore, current testing for UTIs fails patients by missing infections.
In last week’s post I talked about the urinary microbiota – the bacterial communities that have recently been discovered to be present in the urinary tract.
We know now that microbes that live in and on our bodies play a crucial role in health and illness. There are friendly and pathogenic microbes (bacteria, fungi etc.) plus opportunistic microbes that can become pathogenic when left unchecked.
When the delicate balance of good vs bad microbes is disturbed we become prone to an array of health conditions and infections. This is called a ‘dysbiosis’.
The so-called GAG layer plays an important role in protecting the bladder lining (epithelium) against anything that enters the bladder.
When this protective layer is disturbed, the sensitive bladder lining is exposed to irritation and attack. From this, sensitivity, pain and other problems can arise.
A damaged GAG layer has been established to play a big role in the pathogenesis of interstitial cystitis.
Today I’d like to share Kathleen and Roy’s story about how they beat interstitial cystitis. I found this story very moving and inspirational – it shows once again that interstitial cystitis can be overcome.
The cause of interstitial cystitis may be different for each of us and the only way to overcome this debilitating condition is to keep searching for that root cause.
Together with her husband Roy, Kathleen finally found the root cause of her interstitial cystitis and this empowered her to overcome this condition.
This story is an account of Kathleen’s journey with interstitial cystitis, written by her husband Roy.
I hope this story will be an inspiration for you to keep searching for answers… Healing is possible!
In my last post I’ve looked at biofilm infections and why they could be at the root of bladder problems. In this post I’m going to look at potential treatments for biofilm infections.
If you haven’t read my last post yet it might be a good idea to read it now. It explains what biofilms are.
Biofilms have been recognized to play a role in many infections, yet orthodox treatment options are still limited and research is ongoing.
Treating biofilms is difficult because of the limited ability of antibiotic agents to actually get to the bacteria. Natural antibiotics are no exception.
Not everyone with interstitial cystitis is prepared to follow a restricted diet, like the one I’ve outlined in the ‘Interstitial Cystitis Diet’. If you’re one of these people it is a good idea to have a look at the top 10 foods & drinks to avoid with interstitial cystitis I have listed below.